| Venezia FC vs. US Lecce | 8-23-2026
Sunday
TBD | Stadio Pier Luigi Penzo in Sant'Elena, Italy | View Tickets |
| US Lecce vs. AS Roma | 8-31-2026
Monday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| Cagliari Calcio vs. US Lecce | 9-5-2026
Saturday
TBD | Unipol Domus in Lazzaretto, Italy | View Tickets |
| US Lecce vs. AC Monza | 9-13-2026
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| AC Milan vs. US Lecce | 9-20-2026
Sunday
TBD | San Siro in Milan, Italy | View Tickets |
| US Lecce vs. Bologna FC | 10-11-2026
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| Udinese Calcio vs. US Lecce | 10-18-2026
Sunday
TBD | Bluenergy Stadium in Baldasseria, Italy | View Tickets |
| US Lecce vs. Juventus FC | 10-25-2026
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| US Lecce vs. Genoa CFC | 11-1-2026
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| Torino FC vs. US Lecce | 11-7-2026
Saturday
TBD | Stadio Olimpico di Torino in Torino, Italy | View Tickets |
| SS Lazio vs. US Lecce | 11-22-2026
Sunday
TBD | Stadio Olimpico - Rome in Borgata Ottavia, Italy | View Tickets |
| US Lecce vs. Atalanta BC | 11-29-2026
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| SSC Napoli vs. US Lecce | 12-6-2026
Sunday
TBD | Stadio Diego Armando Maradona in Agnano, Italy | View Tickets |
| US Lecce vs. US Sassuolo Calcio | 12-13-2026
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| US Lecce vs. FC Inter Milan | 12-20-2026
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| Como 1907 vs. US Lecce | 1-3-2027
Sunday
TBD | Stadio Giuseppe Sinigaglia in Breccia, Italy | View Tickets |
| US Lecce vs. Parma FC | 1-6-2027
Wednesday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| ACF Fiorentina vs. US Lecce | 1-9-2027
Saturday
TBD | Stadio Artemio Franchi - Florence in Firenze, Italy | View Tickets |
| US Lecce vs. Udinese Calcio | 1-17-2027
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| US Lecce vs. Torino FC | 1-24-2027
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| Genoa CFC vs. US Lecce | 1-30-2027
Saturday
TBD | Stadio Luigi Ferraris in Genova, Italy | View Tickets |
| AC Monza vs. US Lecce | 2-13-2027
Saturday
TBD | U-Power Stadium in Monza, Italy | View Tickets |
| US Lecce vs. Frosinone Calcio | 2-20-2027
Saturday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| Bologna FC vs. US Lecce | 2-28-2027
Sunday
TBD | Stadio Renato Dall'ara Bologna in Bologna, Italy | View Tickets |
| US Lecce vs. Como 1907 | 3-7-2027
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| Parma FC vs. US Lecce | 3-13-2027
Saturday
TBD | Stadio Ennio Tardini in Parma, Italy | View Tickets |
| AS Roma vs. US Lecce | 3-21-2027
Sunday
TBD | Stadio Olimpico - Rome in Borgata Ottavia, Italy | View Tickets |
| US Lecce vs. SS Lazio | 4-4-2027
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| Juventus FC vs. US Lecce | 4-11-2027
Sunday
TBD | Allianz Stadium in Torino, Italy | View Tickets |
| US Sassuolo Calcio vs. US Lecce | 4-17-2027
Saturday
TBD | Mapei Stadium - Stadio Citta del Tricolore in Reggio Emilia, Italy | View Tickets |
| US Lecce vs. AC Milan | 4-25-2027
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| US Lecce vs. Cagliari Calcio | 5-2-2027
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| FC Inter Milan vs. US Lecce | 5-9-2027
Sunday
TBD | San Siro in Milan, Italy | View Tickets |
| US Lecce vs. ACF Fiorentina | 5-16-2027
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
| Atalanta BC vs. US Lecce | 5-22-2027
Saturday
TBD | New Balance Arena in Valtesse, Italy | View Tickets |
| US Lecce vs. Venezia FC | 5-30-2027
Sunday
TBD | Stadio Via del Mare in Lecce, Italy | View Tickets |
