| FSV Mainz 05 vs. SC Paderborn 07 | 8-29-2026
Saturday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| Hamburger SV vs. FSV Mainz 05 | 9-4-2026
Friday
TBD | Volksparkstadion in Hamburg, Germany | View Tickets |
| FSV Mainz 05 vs. Eintracht Frankfurt | 9-11-2026
Friday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| Borussia Monchengladbach vs. FSV Mainz 05 | 9-18-2026
Friday
TBD | Borussia Park in Mönchengladbach, Germany | View Tickets |
| FSV Mainz 05 vs. Bayer 04 Leverkusen | 10-9-2026
Friday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| FSV Mainz 05 vs. SV Werder Bremen | 10-23-2026
Friday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| FSV Mainz 05 vs. FC Bayern Munich | 11-6-2026
Friday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| FC Augsburg vs. FSV Mainz 05 | 11-21-2026
Saturday
TBD | WWK Arena in Augsburg, Germany | View Tickets |
| FSV Mainz 05 vs. FC Union Berlin | 11-27-2026
Friday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| RB Leipzig vs. FSV Mainz 05 | 12-5-2026
Saturday
TBD | Red Bull Arena in Leipzig, Germany | View Tickets |
| FSV Mainz 05 vs. SC Freiburg | 12-11-2026
Friday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| FSV Mainz 05 vs. FC Koln | 12-18-2026
Friday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| Borussia Dortmund vs. FSV Mainz 05 | 1-9-2027
Saturday
TBD | Westfalenstadion in Dortmund, Germany | View Tickets |
| FSV Mainz 05 vs. TSG 1899 Hoffenheim | 1-12-2027
Tuesday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| VfB Stuttgart vs. FSV Mainz 05 | 1-16-2027
Saturday
TBD | MHPArena in Stuttgart, Germany | View Tickets |
| FSV Mainz 05 vs. Hamburger SV | 1-29-2027
Friday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| Eintracht Frankfurt vs. FSV Mainz 05 | 2-7-2027
Sunday
TBD | Deutsche Bank Park in Frankfurt am Main, Germany | View Tickets |
| FSV Mainz 05 vs. Borussia Monchengladbach | 2-12-2027
Friday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| Bayer 04 Leverkusen vs. FSV Mainz 05 | 2-20-2027
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| FSV Mainz 05 vs. FC Schalke 04 | 2-26-2027
Friday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| SV Werder Bremen vs. FSV Mainz 05 | 3-3-2027
Wednesday
TBD | Weserstadion in Bremen, Germany | View Tickets |
| FSV Mainz 05 vs. SV Elversberg | 3-5-2027
Friday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| FC Bayern Munich vs. FSV Mainz 05 | 3-13-2027
Saturday
TBD | Allianz Arena in München, Germany | View Tickets |
| FSV Mainz 05 vs. FC Augsburg | 3-19-2027
Friday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| FSV Mainz 05 vs. RB Leipzig | 4-9-2027
Friday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| SC Freiburg vs. FSV Mainz 05 | 4-16-2027
Friday
TBD | Europa-Park Stadion in Freiburg im Breisgau, Germany | View Tickets |
| FC Koln vs. FSV Mainz 05 | 4-23-2027
Friday
TBD | Rhein Energie Stadion in Köln, Germany | View Tickets |
| FSV Mainz 05 vs. Borussia Dortmund | 5-7-2027
Friday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| TSG 1899 Hoffenheim vs. FSV Mainz 05 | 5-14-2027
Friday
TBD | PreZero Arena - Sinsheim in Sinsheim-Hoffenheim, Germany | View Tickets |
| FSV Mainz 05 vs. VfB Stuttgart | 5-22-2027
Saturday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
