| Bayer 04 Leverkusen vs. FC Union Berlin | 9-5-2026
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| FC Augsburg vs. Bayer 04 Leverkusen | 9-12-2026
Saturday
TBD | WWK Arena in Augsburg, Germany | View Tickets |
| Bayer 04 Leverkusen vs. RB Leipzig | 9-19-2026
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| FSV Mainz 05 vs. Bayer 04 Leverkusen | 10-9-2026
Friday
TBD | Mewa Arena in Mainz, Germany | View Tickets |
| Bayer 04 Leverkusen vs. SC Freiburg | 10-17-2026
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| TSG 1899 Hoffenheim vs. Bayer 04 Leverkusen | 10-23-2026
Friday
TBD | PreZero Arena - Sinsheim in Sinsheim-Hoffenheim, Germany | View Tickets |
| Bayer 04 Leverkusen vs. VfB Stuttgart | 10-31-2026
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| FC Koln vs. Bayer 04 Leverkusen | 11-6-2026
Friday
TBD | Rhein Energie Stadion in Köln, Germany | View Tickets |
| Bayer 04 Leverkusen vs. SC Paderborn 07 | 11-21-2026
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| Borussia Dortmund vs. Bayer 04 Leverkusen | 11-28-2026
Saturday
TBD | Westfalenstadion in Dortmund, Germany | View Tickets |
| Bayer 04 Leverkusen vs. Borussia Monchengladbach | 12-5-2026
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| SV Werder Bremen vs. Bayer 04 Leverkusen | 12-12-2026
Saturday
TBD | Weserstadion in Bremen, Germany | View Tickets |
| Bayer 04 Leverkusen vs. Eintracht Frankfurt | 12-19-2026
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| Hamburger SV vs. Bayer 04 Leverkusen | 1-8-2027
Friday
TBD | Volksparkstadion in Hamburg, Germany | View Tickets |
| FC Bayern Munich vs. Bayer 04 Leverkusen | 1-13-2027
Wednesday
TBD | Allianz Arena in München, Germany | View Tickets |
| Bayer 04 Leverkusen vs. FC Schalke 04 | 1-16-2027
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| Bayer 04 Leverkusen vs. SV Elversberg | 1-23-2027
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| Bayer 04 Leverkusen vs. FC Augsburg | 2-6-2027
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| RB Leipzig vs. Bayer 04 Leverkusen | 2-13-2027
Saturday
TBD | Red Bull Arena in Leipzig, Germany | View Tickets |
| Bayer 04 Leverkusen vs. FSV Mainz 05 | 2-20-2027
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| SC Freiburg vs. Bayer 04 Leverkusen | 2-26-2027
Friday
TBD | Europa-Park Stadion in Freiburg im Breisgau, Germany | View Tickets |
| Bayer 04 Leverkusen vs. TSG 1899 Hoffenheim | 3-3-2027
Wednesday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| VfB Stuttgart vs. Bayer 04 Leverkusen | 3-6-2027
Saturday
TBD | MHPArena in Stuttgart, Germany | View Tickets |
| Bayer 04 Leverkusen vs. FC Koln | 3-13-2027
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| Bayer 04 Leverkusen vs. Borussia Dortmund | 4-3-2027
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| Borussia Monchengladbach vs. Bayer 04 Leverkusen | 4-9-2027
Friday
TBD | Borussia Park in Mönchengladbach, Germany | View Tickets |
| Bayer 04 Leverkusen vs. SV Werder Bremen | 4-17-2027
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| Eintracht Frankfurt vs. Bayer 04 Leverkusen | 4-25-2027
Sunday
TBD | Deutsche Bank Park in Frankfurt am Main, Germany | View Tickets |
| Bayer 04 Leverkusen vs. Hamburger SV | 5-8-2027
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| Bayer 04 Leverkusen vs. FC Bayern Munich | 5-15-2027
Saturday
TBD | Bay Arena in Leverkusen, Germany | View Tickets |
| FC Schalke 04 vs. Bayer 04 Leverkusen | 5-22-2027
Saturday
TBD | Veltins Arena in Gelsenkirchen, Germany | View Tickets |
